内容摘要：The film adaptation will be produced by Blumhouse and Atomic Monster, in association with Kinetic Games Limited. No distributor or release date has been set.

The film adaptation will be produced by Blumhouse and Atomic Monster, in association with Kinetic Games Limited. No distributor or release date has been set.

, and can be treated with antibiotics.Scientists are still searching for answers about how Y. pestis evolved and dispersed, but recent analysis of ancient and modern Y. pestis samples revealed how plague managed to persist among humans for hundreds of years after pandemic waves petered out. After an initial period of high infection rates and rapid mortality — killing infected people within three days — changes to just one gene in the bacterium produced new strains that were less deadly and more transmissible, according to research published Thursday in the journal

Those weakened strains eventually went extinct; the dominant lineage of today’s Y. pestis is the deadlier variety, the study authors reported. However, these findings about historic instances of Y. pestis adaptation could provide important clues to help scientists and physicians manage modern plague outbreaks.Plague’s most common form is bubonic plague, which causes painful swelling in lymph nodes and spreads among people through bites from fleas hitchhiking on infected rats. An outbreak of bubonic plague from 1347 to 1352 in Europe famously killed about 30% to 50% of the continent’s population. But the earliest known bubonic plague outbreak — the Plague of Justinian — took hold in the Mediterranean Basin and lasted from AD 541 to AD 544. Another plague outbreak emerged in China in the 1850s and sparked a major epidemic in 1894. Scientists view modern plague cases as part of this third pandemic.For the new study, scientists collected ancient samples of Y. pestis from human remains dating back to about 100 years after the appearance of the first and second plague pandemics, sampling remains from Denmark, Europe and Russia. After reconstructing the genomes of these plague strains, they compared them with older, ancient strains that dated back to the start of plague pandemics.

The researchers also examined more than 2,700 genomes of modern plague samples from Asia, Africa, and North and South America. One of the study coauthors, Jennifer Klunk, is a product scientist at Daciel Arbor Biosciences, a biotechnology company in Michigan that provided synthetically created molecules for the experiments, but there was no financial gain associated with the research.The researchers found that their newly reconstructed genomes from 100 years into the first two plague pandemics had fewer copies of a gene called pla

which has been recognized for decades as one of the factors that made plague so deadly, according to the study’s co-lead author Ravneet Sidhu, a doctoral student in the McMaster Ancient DNA Centre at McMaster University in Ontario, Canada.

Pla encodes an enzyme that interacts with host proteins, “and one of the functions that it carries out is in breaking down blood clots,” Sidhu told CNN. This ability helps Y. pestis spread into the host’s lymph nodes, where it replicates before attacking the rest of the body.are set to attend the opening-night showing of the musical Les Misérables at the Kennedy Center next week, making a rare public appearance in Washington's nightlife by visiting

The White House confirmed the first couple's attendance to USA TODAY. But they won't be seeing all of the musical's cast members,to sit out of the show that night, CNN and the Washington Post reported.

and second lady Usha Vance will also attend the same showing of Les Misérables. The musical debuts at the John F. Kennedy Center for the Performing Arts on June 11 and runs through July 13."I love the songs, I love the play,"