内容摘要：European Commission President Ursula von der Leyen, center, listens to European Council President Antonio Costa during a meeting between the U.K. and the European Union to discuss closer ties in their first official summit since Brexit, in London, Monday, May 19, 2025.(AP Photo/Kin Cheung, Pool)

European Commission President Ursula von der Leyen, center, listens to European Council President Antonio Costa during a meeting between the U.K. and the European Union to discuss closer ties in their first official summit since Brexit, in London, Monday, May 19, 2025.(AP Photo/Kin Cheung, Pool)

The actors had a dream workspace: The production spent six weeks building a huge, airy kitchen where they work for Talleyrand — unlike the cramped, smoky kitchens that would be more historically accurate.Viewers may feel the need to brush up on their history. The show takes place shortly after Napoleon seized political power in 1799 and became first consul, on his way to later declaring himself emperor.

The actors had to brush up, too.Voisin says he knew about “the victories and defeats of Bonaparte,” but had to learn from scratch the story of Carême.Lyna Khoudri, who plays mysterious Henriette — who may or may not be on her lover’s side — notes: “We’re making a series about the heritage of French culinary art, a story I didn’t know. I found out why we’re so famous for our cuisine in France.”

Da Luz had studied the period at school but dove into it more deeply once she was cast. There was not a lot to read about Agathe, but she read everything she could find. And then, she says, “I let my imagination go,” inspired to bring a woman out of the shadows of history.Jérémie Renier, who plays Talleyrand (actual name Charles Maurice de Talleyrand-Périgord), also engaged in extensive research. “It’s a character who has led a thousand lives,” he said, “who lived through almost a century of history, at a time when people were guillotined for not much. So ... he must have been very clever.”

The show, for Renier, is in large part about ambition. “All these characters have a goal, a dream to achieve,” he says. “The question is, what are we ready to win or lose to achieve this dream?”

The production is lush throughout the whole season, beginning with the gorgeous country homes — filmmakers scouted 60 of them, and chose 12. They created new dinner services to dress the tables, and made 3,000 candles to light all the candelabras — different hues for different rooms. There were 96 vases of fresh flowers at all times in Talleyrand’s home, according to production notes.Los investigadores esperan que lo que aprendan de KJ ayude a otros pacientes con enfermedades raras.

Las terapias génicas, que pueden ser extremadamente costosas de desarrollar, generalmente se dirigen a trastornos más comunes en parte por razones financieras simples: más pacientes significan potencialmente más ventas, lo que puede ayudar a pagar los costos de desarrollo y generar más ganancias. La primera terapia CRISPR aprobada por la Administración de Alimentos y Medicamentos de Estados Unidos (FDA), por ejemplo, trata la enfermedad de células falciformes, un trastorno sanguíneo doloroso que afecta a millones en todo el mundo.Musunuru dijo que el trabajo de su equipo, financiado en parte por los Institutos Nacionales de Salud de Estados Unidos, mostró que crear un tratamiento personalizado no tiene que ser prohibitivamente caro. El costo “no estaba muy lejos” de los más de 800.000 dólares de un trasplante de hígado promedio y el cuidado relacionado, indicó.

“A medida que mejoremos en la creación de estas terapias y acortemos aún más el tiempo, las economías de escala entrarán en juego y esperaría que los costos disminuyan”, dijo Musunuru.Los científicos tampoco tendrán que rehacer todo el trabajo inicial cada vez que creen una terapia personalizada, dijo Bhoopalan, porque esta investigación “prepara el escenario” para tratar otras condiciones raras.