内容摘要：, which owns and operates Facebook and Instagram, supports the legislation.

, which owns and operates Facebook and Instagram, supports the legislation.

Gene therapies, which can be extremely expensive to develop, generally target more common disorders in part for simple financial reasons: more patients mean potentially more sales, which can help pay the development costs and generate more profit. The first CRISPR therapy, for example, treats sickle cell disease, a painful blood disorder affecting millions worldwide.

Musunuru said his team’s work —— showed that creating a custom treatment doesn’t have to be prohibitively expensive. The cost was “not far off” from the $800,000-plus for an average liver transplant and related care, he said.“As we get better and better at making these therapies and shorten the time frame even more, economies of scale will kick in and I would expect the costs to come down,” Musunuru said.

Scientists also won’t have to redo all the initial work every time they create a customized therapy, Bhoopalan said, so this research “sets the stage” for treating other rare conditions.Carlos Moraes, a neurology professor at the University of Miami who wasn’t involved with the study, said research like this opens the door to more advances.

“Once someone comes with a breakthrough like this, it will take no time” for other teams to apply the lessons and move forward, he said. “There are barriers, but I predict that they are going to be crossed in the next five to 10 years. Then the whole field will move as a block because we’re pretty much ready.”

The Associated Press Health and Science Department receives support from the Howard Hughes Medical Institute’s Science and Educational Media Group and the Robert Wood Johnson Foundation. The AP is solely responsible for all content.The report described “severe corrosion” in pipes and protective barriers around oil tanks in the vessel Fluminense, off Brazil.

Two workers were left “with moderate to severe burns” after an incident on a vessel off the U.S. coast in 2016.There were “degraded facilities” on the gas-producing ship Prelude anchored off Australia, where fire broke out in 2021. In 2023, more than a year after the safety report, problems on the Prelude persisted, according to Australian regulators who found health and safety violations related to “exposure to chemicals and risk of an explosion.” They ordered improvements.

In the case of the Prelude, Shell said a dedicated local team of safety engineers and experts looked after the vessel but didn’t provide more details.Other incidents have been reported by regulators or in the press. For example, another Shell ship off Nigeria, the Sea Eagle, began to take on seawater in 2022 and needed urgent repairs, something Cox said was highly unusual for floating production vessels.