内容摘要：to lead the Archdiocese of Washington in 2019 and made him the first Black cardinal from the U.S. in 2020. Gregory, 77, retired this year from leading the prominent archdiocese, which he shepherded through significant turmoil. Its two previous leaders,

to lead the Archdiocese of Washington in 2019 and made him the first Black cardinal from the U.S. in 2020. Gregory, 77, retired this year from leading the prominent archdiocese, which he shepherded through significant turmoil. Its two previous leaders,

Doctors are moving from those one-off experiments to more formal studies. As they monitor Andrews’ recovery, doctors at Mass General Brigham have Food and Drug Administration permission to perform two additional transplants in their pilot study, using gene-edited pig kidneys supplied by biotech eGenesis.And United Therapeutics, another developer of gene-edited pig organs, just won FDA approval for the world’s first clinical trial of xenotransplantation. Initially, six patients will receive pig kidneys — and if they fare well over six months, up to 50 additional patients will receive transplants.

“This is uncharted territory,” said Mass General’s Dr. Tatsuo Kawai, who led both Andrews’ surgery and the world’s first pig kidney transplant last year. But with lessons from animal research and the prior human attempts, he said, “I’m very optimistic. And hopefully we can get to survival, kidney survival, for over two years.”so their organs are more humanlike to address the transplant shortage. More than 100,000 people are on the U.S. transplant list, most who need a kidney, and thousands die waiting.Andrews’ kidneys abruptly failed about two years ago, and the Concord, New Hampshire, grandfather struggled with fatigue and complications from dialysis. He’s on the transplant list but doctors warned it was a long shot. It can take seven years or more for people with Andrews’ blood type to find a matching kidney. Meanwhile, people slowly get sicker on dialysis — five-year survival is about 50% — and Andrews already had had a heart attack.

“I have seen my mortality and I was ready to fight,” Andrews said. So he asked Mass General if he could get a pig kidney instead. “I told them. ‘Anything, I’ll do anything. You give me a list of things you want me to do and I’ll do it.’”Mass General transplant nephrologist Dr. Leonardo Riella said Andrews was weak and struggling with diabetes, including a slow-healing diabetic foot ulcer that hindered walking. He’d have to get more fit to be a candidate.

Andrews started physical therapy and returned six months later about 30 pounds lighter and “running down the hallway almost,” Riella recalled. “He was just, you know, a different person,” so they started checking if he’d qualify for the pilot study.

One big question was cardiac fitness: Mass General’sWith support from friendly countries including the U.S., a treaty ally, Marcos emerged as the

of China’s actions in the disputed South China Sea while contending with an array of longstanding domestic issues including inflation, delayed fulfillment of a campaign promise to bring down the price of rice and many reports of kidnappings and other crimes.Teodoro told The Associated Press in March that China’s

in the disputed waters were now considered the greatest threat to the Philippines’ national security and should also be regarded as a global threat because it could choke a trade route that is crucial for global supply chains.“The greatest external threat actually is Chinese aggression, Chinese expansionism and the attempt by China to change the international law through the use of force or acquiescence … or its attempt to reshape the world order to one that it controls,” Teodoro told the AP.