内容摘要：Beckham played 115 times for his country as well as for Manchester United, LA Galaxy, Paris St-Germain and AC Milan, retiring in 2013.

Beckham played 115 times for his country as well as for Manchester United, LA Galaxy, Paris St-Germain and AC Milan, retiring in 2013.

Wegovy and Mounjaro jabs are currently only available on the NHS through specialist weight management clinics, but they can also be bought privately.The drugs will be offered to millions of the most obese people on the NHS over the next few years, but experts warn services are already struggling to deal with unprecedented demand.

There are two drugs on the market - semaglutide, marketed under the brand name Wegovy, and tirzepatide, sold as Mounjaro. Semaglutide is also used in the type 2 diabetes treatment Ozempic.Both Wegovy and Mounjaro are given as weekly injections via pre-filled pens that can be self-administered into the upper arm, thigh or stomach.They work as an appetite suppressant by mimicking a hormone called glucagon-like peptide-1 (GLP-1).

This is an intestinal hormone which is released after eating, and typically makes people feel fuller.Mounjaro also affects another hormone, glucose-dependent insulinotropic polypeptide (GIP), which affects metabolism and helps regulate energy balance.

Patients generally start on a low dose which is gradually increased until they reach a higher maintenance dose.

The UK's medicines regulator, the MHRA, says the lack of information about how the drugs could affect unborn children means the injections must not be taken:"If you're running up to 50 miles (80km) a week like me, you have to change your trainers every 10 weeks," he said.

Mr Madelaine will run in the Swansea Half Marathon on 8 June.The resignation of Zia Yusuf as Reform UK's chairman matters because he was a central character in the stand out trend in British politics since the general election – the rise and rise of Nigel Farage's party.

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