内容摘要：Many are making headway in their communities and paving the way for other places.

Many are making headway in their communities and paving the way for other places.

but with major restrictions on who can get it — and Tuesday’s guidance mirrors those restrictions. The approval came after Trump appointees overruled FDA scientists’ earlier plans to approve the shot without restrictions.A vial of Moderna COVID-19 vaccine rests on a table at an inoculation station in Jackson, Miss., on July 19, 2022. (AP Photo/Rogelio V. Solis, File)

A vial of Moderna COVID-19 vaccine rests on a table at an inoculation station in Jackson, Miss., on July 19, 2022. (AP Photo/Rogelio V. Solis, File)Pfizer and Moderna, makers of the most commonly used COVID shots, each said they would continue to work with the agency.For years, federal health officials have told most Americans to expect annual updates to COVID-19 vaccines, similar to the annual flu shot. Just like with flu vaccines, until now the FDA has approved updated COVID shots so long as they show as much immune protection as the previous year’s version.

But FDA’s new guidance appears to be the end of that approach, according to Prasad and, who co-authored the journal paper and joined the FDA webcast.

Prasad and Makary criticized the U.S.’s “one-size-fits-all,” contrasting it with some European countries that recommend boosters based on age, risk and other factors.

Prasad said the FDA will ask all manufacturers to do new clinical trials in healthy people ages 50 to 64, randomly assigning them to get a vaccine or a placebo and tracking outcomes with special attention to severe disease, hospitalization or death. Companies might need to repeat that requirement for future vaccine approvals if there’s a large virus mutation rather than the past year’s incremental evolution. Companies are also free to test their vaccines for approval in younger adults and children, Prasad said, adding “this is a free country.”for drinking water alarms him. The department’s press release on Tuesday, which announced the Food and Drug Administration plans to remove fluoride supplements for children from the market, wrongly claimed that fluoride “kills bacteria from the teeth,” Simpson noted. He explained to Kennedy that fluoride doesn’t kill bacteria in the mouth but instead makes tooth enamel more resistant to decay.

“I will tell you that if you are successful in banning fluoride … we better put a lot more money into dental education because we’re going to need a lot more dentists,” Simpson added.Kennedy was pressed repeatedly on the

he’s delivered on vaccines, which public health experts have said are hampering efforts to containnow in at least 11 states.